← All decks
Radiology
Congenital Zika Virus Syndrome
Built from Obstetric Imaging
What’s inside
10 sections · 51 slides
Overview
- Overview of congenital Zika virus syndrome
Background and epidemic history
From an island outbreak to a worldwide alarm
- Emergence of Zika virus as a public health threat
- Course of the Zika virus epidemic
- Definition of congenital Zika virus syndrome
- Zika virus and its viral relatives
- Zika virus infection in adults and children
Prevalence and epidemiology
How far the virus spreads, and how the wave ends
- Spread of Zika virus through a population
- Modelling of the French Polynesia outbreak
- Burn-out of regional epidemics
- 174,003
- Confirmed congenital cases in Brazil
- Monthly notifications of congenital Zika virus syndrome in Brazil
- Trend in Brazilian notifications
- Spread beyond Brazil
Transmission and pathophysiology
How the virus travels, and what it does to the fetal brain
- Routes of Zika virus transmission
- Placental route to the fetus
- Sequence from mosquito bite to fetal brain injury
- Target cells in the fetal brain
- Spectrum of severity
Clinical presentation and diagnosis
What the mother feels, and what the newborn shows
- Maternal clinical presentation
- Recognition of affected newborns
- Diagnosis in the absence of microcephaly
- Maternal laboratory diagnosis
Imaging findings
What ultrasound and magnetic resonance imaging show
- Imaging features of congenital Zika virus syndrome
- Ultrasound findings inside the fetal brain
- Structures that fail to develop
- Fetal microcephaly on ultrasound
- Ventriculomegaly with porencephalic cysts
- Punctate calcifications at the caudate nucleus
- Close-up of the caudate calcifications
Extracerebral findings and magnetic resonance imaging
Beyond the brain, and when sound waves are not enough
- Periventricular white matter change and delayed folding
- Extracerebral findings
- Microphthalmia on fetal ultrasound
- Subtle early findings
- Magnetic resonance imaging
- Brain atrophy on fetal magnetic resonance imaging
- Classic imaging triad
- Interpretation of the classic triad
Differential diagnosis
Look-alikes that the scan alone cannot separate
- TORCH intrauterine infections
- Overlap with congenital cytomegalovirus infection
- Severe congenital cytomegalovirus infection
- Non-infectious mimics
Treatment and counselling
What can and cannot be offered
- Treatment options
Advice for the referring physician
History, referral and follow-up in practice
- Advice for the referring physician
- Surveillance in an affected pregnancy
- Key points
- Sources of current guidance
- References
- References (continued)
- References (continued)
- Obstetric Imaging: Fetal Diagnosis and Care, 2nd Edition