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Dermatology

Human Herpesviruses

Built from Dermatology, 5th Edition

What’s inside

8 sections · 168 slides

  1. 01

    Overview

    • What is a human herpesvirus
    • Herpesvirus infection cycle
    • Human herpesvirus subfamilies
    • The eight human herpesviruses: classification and differential diagnoses - profile
    • The eight human herpesviruses: classification and differential diagnoses - profile (continued)
    • The eight human herpesviruses: classification and differential diagnoses - differential diagnoses
    • The eight human herpesviruses: classification and differential diagnoses - differential diagnoses (continued)
    • The eight human herpesviruses: classification and differential diagnoses - differential diagnoses (continued)

    8 slides

  2. 02

    Herpes Simplex Viruses

    HSV-1 and HSV-2: lifelong viruses that cause orolabial and genital infections

    • What HSV-1 and HSV-2 cause
    • History of herpes simplex virus
    • Epidemiology: how common is HSV
    • How HSV spreads and stays hidden
    • How the immune system fights HSV, and how HSV fights back
    • HSV and the immune system: responses and evasion tactics
    • Primary orolabial herpes infection
    • Primary versus recurrent herpes simplex lesions
    • Recurrent orolabial herpes (cold sores)
    • Recurrent facial herpes simplex virus infection
    • Recurrent herpes simplex virus type 1 on the cheek
    • Primary genital herpes
    • Primary genital herpes
    • Primary genital herpes, additional presentations
    • Recurrent genital herpes
    • Recurrent genital herpes
    • Recurrent genital herpes simplex virus infection
    • Herpes simplex virus infection of the penis and scrotum
    • Recurrent herpes simplex virus infection on the penis
    • Recurrent genital herpes with scalloped ulcer borders
    • Other places HSV can appear
    • Eczema herpeticum
    • Eczema herpeticum of a major skin fold
    • Eczema herpeticum of the face
    • Eczema herpeticum of the groin
    • Herpetic whitlow
    • Herpetic whitlow in a child and an adult
    • Herpes simplex virus in uncommon locations
    • Severe and chronic HSV in immunocompromised patients
    • Herpes simplex virus infection in immunocompromised hosts
    • HSV in the eye and brain
    • Neonatal HSV infection
    • Neonatal herpes simplex virus infection
    • Other clinical presentations of herpes simplex virus infection - Clinical setting and HSV type
    • Other clinical presentations of herpes simplex virus infection - Clinical setting and HSV type (continued)
    • Other clinical presentations of herpes simplex virus infection - Clinical setting and HSV type (continued)
    • Other clinical presentations of herpes simplex virus infection - Findings
    • Other clinical presentations of herpes simplex virus infection - Findings (continued)
    • Other clinical presentations of herpes simplex virus infection - Findings (continued)
    • Diagnosing HSV infection
    • Tzanck smear in herpes simplex virus infection
    • Histology of herpes simplex virus infection
    • Telling HSV apart from look-alikes
    • Treating orolabial herpes
    • Treating genital herpes
    • Drug-resistant HSV and HIV co-infection
    • Preventing HSV transmission
    • Antiviral therapy for herpes simplex virus and varicella-zoster virus
    • Antiviral therapy for herpes simplex virus and varicella-zoster virus (continued)
    • Antiviral therapy for herpes simplex virus and varicella-zoster virus (continued)
    • Antiviral therapy for herpes simplex virus and varicella-zoster virus (continued)
    • Dose reductions for acyclovir, valacyclovir, and famciclovir in renal disease - Acyclovir
    • Dose reductions for acyclovir, valacyclovir, and famciclovir in renal disease - Acyclovir (continued)
    • Dose reductions for acyclovir, valacyclovir, and famciclovir in renal disease - Valacyclovir
    • Dose reductions for acyclovir, valacyclovir, and famciclovir in renal disease - Valacyclovir (continued)
    • Dose reductions for acyclovir, valacyclovir, and famciclovir in renal disease - Famciclovir
    • Dose reductions for acyclovir, valacyclovir, and famciclovir in renal disease - Famciclovir (continued)

    57 slides

  3. 03

    Varicella-Zoster Virus

    VZV (HHV-3): chickenpox the first time, shingles when it comes back

    • What VZV causes
    • History of chickenpox and shingles
    • Epidemiology: the vaccine changed the picture
    • How varicella spreads through the body
    • How chickenpox spreads and shingles reactivates
    • What chickenpox looks like
    • Varicella lesions in different stages of evolution
    • Varicella lesions, additional presentation
    • Varicella papulovesicles and hemorrhagic crusts
    • Varicella, additional stages of evolution
    • Chickenpox complications
    • Varicella in HIV infection
    • How shingles starts
    • Distribution of dermatomes
    • Evolution of herpes zoster lesions
    • Facial herpes zoster
    • Complications of shingles
    • Clinical findings by dermatome involved in herpes zoster - Cutaneous findings
    • Clinical findings by dermatome involved in herpes zoster - Cutaneous findings (continued)
    • Clinical findings by dermatome involved in herpes zoster - Extracutaneous findings
    • Clinical findings by dermatome involved in herpes zoster - Extracutaneous findings (continued)
    • Ophthalmic herpes zoster
    • Multi-dermatomal herpes zoster
    • Herpes zoster in different dermatomes
    • Close-up of herpes zoster vesicles
    • Herpes zoster with cupping-related purpura
    • A new disease growing where shingles once was
    • Granulomatous dermatitis at a healed herpes zoster site
    • Cutaneous disorders that can develop within sites of herpes zoster
    • Cutaneous disorders that can develop within sites of herpes zoster (continued)
    • Shingles in immunocompromised patients
    • Chronic verrucous zoster in HIV infection
    • Disseminated varicella-zoster virus infection
    • Herpes zoster after varicella vaccination
    • Diagnosing chickenpox and shingles
    • Direct fluorescent antibody assay for herpes simplex virus
    • Telling VZV rashes apart from look-alikes
    • Coxsackievirus A6 infection mimicking varicella
    • Treating chickenpox
    • Preventing chickenpox after exposure
    • The chickenpox vaccine
    • ACIP recommendations for varicella vaccine administration
    • ACIP recommendations for varicella vaccine administration (continued)
    • Treating shingles and its nerve pain
    • Shingles vaccines: an evolving story

    45 slides

  4. 04

    Epstein-Barr Virus

    HHV-4: the virus behind infectious mononucleosis and much more

    • What EBV causes
    • Epidemiology of EBV
    • How EBV infects and hides
    • Infectious mononucleosis: the classic picture
    • Genital ulceration in primary Epstein-Barr virus infection
    • Ampicillin-induced eruption in infectious mononucleosis
    • EBV complications and other skin findings
    • EBV-associated disorders
    • EBV-associated disorders (continued)
    • Diagnosing EBV infection
    • EBV serologies: timing and interpretation
    • More ways to detect EBV, and ruling out look-alikes
    • Treating infectious mononucleosis

    13 slides

  5. 05

    Cytomegalovirus

    HHV-5: usually silent, but dangerous to newborns and the immunocompromised

    • What CMV causes
    • History and epidemiology of CMV
    • How CMV spreads and stays hidden
    • CMV in healthy adults: a mono-like illness
    • Cutaneous manifestations of CMV infection
    • Congenital CMV: the TORCH syndrome
    • TORCH syndrome due to cytomegalovirus
    • CMV in immunocompromised patients
    • Cutaneous ulcers in disseminated cytomegalovirus infection
    • Histology of cytomegalovirus infection
    • Diagnosing and ruling out CMV
    • Preventing and treating CMV infection
    • Treatment options for CMV infection in immunocompromised patients

    13 slides

  6. 06

    Human Herpesvirus 6

    HHV-6: the cause of roseola, a common childhood fever-and-rash illness

    • What HHV-6 causes
    • Epidemiology and pathogenesis of HHV-6
    • What roseola looks like
    • Exanthem subitum (roseola infantum)
    • HHV-6 in immunocompromised patients, diagnosis, and treatment

    5 slides

  7. 07

    Human Herpesvirus 7

    HHV-7: a close relative of HHV-6, still poorly understood

    • HHV-7: what we know
    • Conditions linked to HHV-7

    2 slides

  8. 08

    Human Herpesvirus 8

    HHV-8: the virus behind Kaposi sarcoma

    • What HHV-8 causes
    • Who gets HHV-8, and where
    • How HHV-8 causes Kaposi sarcoma
    • Five types of Kaposi sarcoma
    • What Kaposi sarcoma looks like
    • Classic Kaposi sarcoma
    • Classic Kaposi sarcoma, additional presentations
    • Diagnosing and treating Kaposi sarcoma
    • LANA-1 immunostaining in Kaposi sarcoma
    • Eight viruses, one shared strategy
    • The eight human herpesviruses at a glance
    • References
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    • References
    • Dermatology, 5th Edition (2-Volume Set)

    25 slides