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Dermatology
Adnexal Neoplasms
Built from Dermatology, 5th Edition
What’s inside
8 sections · 148 slides
Overview
- What is an adnexal neoplasm
- Key features of this chapter
- How the glands develop together
- Folliculosebaceous-apocrine unit and eccrine gland
- Three clues used to classify a tumor
- Recognising differentiation under the microscope
Follicular hamartomas
Hair follicle nevus, trichofolliculoma, fibrofolliculoma, nevus sebaceus, mixed tumor
- Follicular hamartomas as a group
- Hair follicle nevus
- Trichofolliculoma
- Trichofolliculoma: wispy hairs from a central pore
- Trichofolliculoma: radiating follicles around a central cyst
- Trichofolliculoma - related hamartoma variants
- Fibrofolliculoma, perifollicular fibroma, trichodiscoma
- Birt-Hogg-Dube syndrome
- Fibrofolliculomas in Birt-Hogg-Dube syndrome - clinical and histology
- Guidelines for diagnosis and evaluation of Birt-Hogg-Dube syndrome
- Guidelines for diagnosis and evaluation of Birt-Hogg-Dube syndrome (continued)
- Guidelines for diagnosis and evaluation of Birt-Hogg-Dube syndrome (continued)
- Facial papules in inherited syndromes - Gardner and Down syndrome
- Fibrofolliculomas of the lateral cheek in Birt-Hogg-Dube syndrome
- Widespread fibrofolliculomas of the head and neck
- Fibrofolliculoma papules of the face
- Fibrofolliculoma - pathology and treatment
- Nevus sebaceus
- Nevus sebaceus: linear scalp plaque
- Nevus sebaceus - the genetics
- Secondary tumors that grow within nevus sebaceus
- Syringocystadenoma papilliferum arising in nevus sebaceus
- Nevus sebaceus - epidermal and sebaceous-gland changes on histology
- Nevus sebaceus of the scalp with surrounding alopecia
- Nevus sebaceus - treatment
- Mixed tumor (chondroid syringoma)
- Mixed tumor: exophytic nodule on the lip
- Mixed tumor with apocrine ('decapitation') differentiation
- Mixed tumor with eccrine-type ductal differentiation
- Mixed tumor - treatment
Follicular germinative and matrical tumors
Trichoepithelioma, trichoblastoma, and pilomatricoma - benign forms and their carcinomas
- Trichoepithelioma and trichoblastoma - naming
- Trichoepithelioma - clinical features
- Multiple familial trichoepitheliomas of the midface
- Trichoepithelioma/trichoblastoma - pathology
- Trichoepithelioma: follicular germinative cell clusters
- Trichoepithelioma/trichoblastoma - treatment
- Desmoplastic trichoepithelioma
- Desmoplastic trichoepithelioma: basaloid cords in sclerotic stroma
- Pilomatricoma
- Pilomatricoma - clinical features
- Pilomatricoma in two children
- Pilomatricoma: firm papule on a child's cheek
- Pilomatricoma - pathology
- Pilomatricoma: matrical cells transitioning to shadow cells
- Pilomatricoma - treatment, and pilomatrical carcinoma
Tricholemmal and superficial follicular tumors
Tricholemmoma, tumor of follicular infundibulum, trichoadenoma, proliferating pilar tumor
- Tricholemmoma
- Tricholemmoma - Cowden syndrome
- Tricholemmoma: pale outer-sheath cells attached to the epidermis
- Tricholemmoma - pathology and treatment
- Tricholemmal carcinoma
- Tumor of follicular infundibulum
- Tumor of follicular infundibulum: clinical and pathology
- Tumor of follicular infundibulum: hypopigmented papules mimicking fibrofolliculoma
- Tumor of follicular infundibulum - treatment
- Trichoadenoma
- Trichoadenoma: keratin-filled cysts in sclerotic stroma
- Proliferating pilar tumor
- Proliferating pilar tumor: solid and cystic keratinizing patterns
- Proliferating pilar tumor - pathology and treatment
Sebaceous differentiation
Sebaceous hyperplasia, adenoma, sebaceoma, and sebaceous carcinoma
- Sebaceous gland hyperplasia
- Sebaceous hyperplasia: yellow papules with central dell
- Widespread sebaceous hyperplasia in a patient on long-term cyclosporine
- Sebaceous hyperplasia - treatment
- Sebaceous adenoma, sebaceoma, and terminology
- Muir-Torre syndrome
- Sebaceous adenoma (sebaceoma): seboblasts and mature sebocytes
- Sebaceous adenoma of the nose in Muir-Torre syndrome
- Sebaceous adenoma - treatment
- Sebaceous carcinoma
- Sebaceous carcinoma: atypical nuclei and necrotic cells
- Sebaceous carcinoma - pathology and treatment
Apocrine (or eccrine) differentiation
Syringoma, poroma, hidradenoma, spiradenoma, cylindroma, and their carcinomas
- Why apocrine vs eccrine is so hard to call
- Syringoma
- Syringomas: periorbital and truncal patterns
- Vulvar syringomas with surrounding pigmentation
- Syringoma - pathology and treatment
- Syringoma: comma-shaped nests with central ducts
- Poroma
- Poroma: eroded vascular plaques
- Poroma requiring biopsy for diagnosis
- Poroma: eroded red plaque on the sole
- Poroma - genetics and growth pattern
- Poroma, juxta-epidermal pattern: poroid cords in a vascular stroma
- Poroma, intradermal pattern: ductal differentiation and central necrosis
- Poroma - a diagnostic quirk, and treatment
- Hidradenoma
- Hidradenoma: solid-cystic nodule with pale, clear-celled cytoplasm
- Hidradenoma - pathology and treatment
- Apocrine adenoma group
- Syringocystadenoma papilliferum
- Syringocystadenoma papilliferum: crusted grouped nodules
- Syringocystadenoma papilliferum: papillary fronds with a plasma-cell infiltrate
- Hidradenoma papilliferum
- Hidradenoma papilliferum: arborizing glandular and papillary structures
- Spiradenoma and cylindroma - a related pair
- Spiradenoma
- Spiradenoma: trabecular nodules with basaloid cells
- Cylindroma
- Cylindromas: scalp nodules
- Cylindroma: jigsaw-puzzle nests rimmed by basement membrane
- Cylindroma: basaloid nests with basement-membrane material
- Spiradenoma and cylindroma - treatment
- Carcinomas of apocrine lineage - naming rules
- Microcystic adnexal carcinoma
- Microcystic adnexal carcinoma: subtle expanding plaque
- Microcystic adnexal carcinoma: ductal and follicular differentiation
- Microcystic adnexal carcinoma - pathology
- Porocarcinoma
- Porocarcinoma: rapid growth and erosion
- Porocarcinoma: infiltrating nests with ductal differentiation
- More apocrine-lineage carcinomas
- Adenoid cystic and cribriform carcinomas
- Mucinous and secretory carcinomas
- Adnexal carcinomas - overall treatment
Eccrine differentiation
Eccrine nevus, porokeratotic eccrine nevus, syringofibroadenoma, digital papillary tumors
- Eccrine nevus (hamartoma)
- Porokeratotic eccrine ostial and dermal duct nevus
- Porokeratotic eccrine ostial and dermal duct nevus
- Porokeratotic eccrine nevus: linear palm plaques with keratotic spines
- Syringofibroadenoma
- Papillary adenoma and adenocarcinoma of the digit
- Papillary adenocarcinoma of the digit: cystic tubular and papillary areas
- Papillary adenoma/adenocarcinoma - treatment
Summary and references
Key classification takeaways, syndromes to remember, and the chapter's reference list
- The four differentiation groups, at a glance
- Syndromes to remember
- Clues that should raise concern for malignancy
- Take-home points
- References
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- References
- Dermatology, 5th Edition (2-Volume Set)