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Cardiology

Renal and Mesenteric Artery Stenosis and Intervention

Built from Cardiovascular Catheterization and Intervention: A Textbook of Coronary, Peripheral, and Structural Heart Disease

What’s inside

8 sections · 129 slides

  1. 01

    Renal Artery Stenosis

    • Definition and etiologies of renal artery stenosis
    • Atherosclerotic disease versus fibromuscular dysplasia
    • Prevalence of atherosclerotic renal artery stenosis
    • Epidemiology of fibromuscular dysplasia
    • Pathophysiology: renin-angiotensin-aldosterone activation
    • Progression to ischemic nephropathy
    • Pathway from renal artery disease to irreversible kidney damage
    • Renal artery stenosis and congestive heart failure

    8 slides

  2. 02

    Clinical Manifestations and Diagnosis

    • Hypertensive clues to renal artery stenosis
    • Cardiovascular and renal clues to renal artery stenosis
    • Duplex ultrasound criteria for renal artery stenosis
    • Renal duplex ultrasound of a significant stenosis
    • CT and MR angiography in renal artery stenosis
    • Catheter angiography and tests no longer recommended
    • Imaging pathway in suspected fibromuscular dysplasia

    7 slides

  3. 03

    Evidence for Revascularization

    • STAR trial: design and results
    • Limitations of the STAR trial
    • ASTRAL trial: design and results
    • Limitations of the ASTRAL trial
    • CORAL trial: design and entry criteria
    • CORAL trial: outcomes
    • Criticism of the CORAL trial design
    • Meta-analyses of the randomized evidence
    • Observational blood pressure data: Dorros and ASPIRE-2
    • RENAISSANCE and Courand cohorts
    • Pressure gradient as a predictor of blood pressure response
    • Renal function outcomes after renal artery intervention
    • Predictors of renal benefit after revascularization
    • Predictors of cardiovascular outcome and mortality
    • Patient selection as the governing principle

    15 slides

  4. 04

    Indications for Intervention

    • Fibromuscular dysplasia: disease definition
    • Angiographic patterns of fibromuscular dysplasia
    • Clinical clues to fibromuscular dysplasia related hypertension
    • Revascularization outcomes in fibromuscular dysplasia
    • Heart failure and flash pulmonary edema
    • Mechanism of flash pulmonary edema in renal artery stenosis
    • Recommendation in heart failure and flash pulmonary edema
    • Resistant hypertension: definition and associated renal disease
    • Revascularization in resistant hypertension
    • Progressive renal failure and rate of decline
    • Advanced kidney disease and recovery of glomerular filtration
    • Guideline recommendations in progressive chronic kidney disease

    12 slides

  5. 05

    Renal Artery Intervention

    • Access and catheter selection for renal artery intervention
    • The no-touch technique
    • No-touch technique for engaging the renal artery
    • Intravascular ultrasound before intervention
    • Ostial renal artery stenosis with intravascular ultrasound correlation
    • Severe ostial stenosis on digital subtraction angiography
    • Calcified atherosclerotic plaque on intravascular ultrasound
    • Predilatation and stent sizing
    • Stent selection in the renal artery
    • Post-stent assessment and final angiography
    • Intravascular ultrasound after stent placement
    • Physiological assessment of intermediate renal lesions
    • Sequence of a renal artery intervention
    • Challenging anatomy: downward renal artery angulation
    • Radial approach technique for the renal artery
    • Heavily calcified renal artery lesions
    • Technique in fibromuscular dysplasia
    • Complications of renal artery intervention
    • Management of renal artery perforation
    • Follow-up after renal artery stenting
    • Renal artery stenosis: conclusion

    21 slides

  6. 06

    Acute Mesenteric Ischemia

    • Mesenteric ischemia: definition and burden
    • Causes of acute mesenteric ischemia
    • Arterial embolism and in-situ thrombosis
    • Mesenteric venous thrombosis and non-occlusive ischemia
    • Tissue injury in mesenteric ischemia
    • Epidemiology of acute mesenteric ischemia
    • Clinical presentation of acute mesenteric ischemia
    • Laboratory findings in acute mesenteric ischemia
    • Imaging in acute mesenteric ischemia
    • Endovascular versus open revascularization
    • Endovascular modalities in acute mesenteric ischemia
    • Multidisciplinary decision-making in acute mesenteric ischemia

    12 slides

  7. 07

    Chronic Mesenteric Ischemia

    • Etiology of chronic mesenteric ischemia
    • Collateral circulation and the two-vessel rule
    • Non-occlusive chronic mesenteric ischemia
    • Median arcuate ligament syndrome
    • Management of median arcuate ligament syndrome
    • Epidemiology of chronic mesenteric ischemia
    • Prevalence of mesenteric artery stenosis
    • Clinical presentation of chronic mesenteric ischemia
    • Laboratory testing and duplex ultrasound in chronic mesenteric ischemia
    • Cross-sectional imaging in chronic mesenteric ischemia
    • Functional testing and digital subtraction angiography
    • Endovascular outcomes in chronic mesenteric ischemia
    • Meta-analysis of endovascular treatment for chronic mesenteric ischemia
    • Recommendation for endovascular treatment of chronic mesenteric ischemia

    14 slides

  8. 08

    Mesenteric Artery Intervention

    • Access and equipment for mesenteric intervention
    • Fluoroscopic angulation and initial angiography
    • Collateral pathways of the mesenteric circulation
    • Choice of target vessel for mesenteric intervention
    • Intravascular ultrasound sizing and predilatation
    • Stent deployment and final assessment
    • Superior mesenteric artery stenosis treated with a drug-eluting stent
    • Occluded celiac trunk with severe superior mesenteric artery stenosis
    • Heavily calcified mesenteric lesions
    • Endovascular treatment of acute mesenteric ischemia in practice
    • Complications of mesenteric artery intervention
    • Mesenteric intervention: conclusion
    • Key points: renal artery stenosis
    • Key points: mesenteric ischemia
    • References
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    • Cardiovascular Catheterization and Intervention: A Textbook of Coronary, Peripheral, and Structural Heart Disease
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    32 slides